197250-15-0

197250-15-0 structure

Name: GAP 26 trifluoroacetate salt
Chemical Name: Gap 26
CAS Number: 197250-15-0
Molecular Formula: C₇₀H₁₀₆N₁₉O₁₉S
Molecular Weight: 1550.78
Catalog: Peptides
Create Date: 2018-12-23 18:50:16
Modify Date: 2024-01-05 11:27:56
Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.

Name	Gap 26
Synonyms	Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg M.W. 1550.78 C70H107N19O19S VCYDKSFPISHVR

Description	Gap 26 is a connexin mimetic peptide corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker.
Related Catalog	Signaling Pathways >> Cytoskeleton >> Gap Junction Protein Research Areas >> Cardiovascular Disease Peptides
Target	Gap Junction Protein[1]
In Vitro	Gap 26 is corresponding to the residues 63-75 of connexin 43, which is a gap junction blocker. Gap 26 (100-300 μM) dose-dependently reduces the rhythmic responses of rabbit superior mesenteric arteries, with IC50 of 28.4 ± 3.4 μM[1]. Gap 26 abolishes the inositol-1,4,5-trisphosphate (InsP3)-triggered ATP response and reduces the ATP release, but has no effect on gap junctional coupling[2].
References	[1]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110. [2]. Braet K, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48.