41941-56-4
41941-56-4 structure
- Name: 8-Cl-cAMP
- Chemical Name: 8-chloro-camp
- CAS Number: 41941-56-4
- Molecular Formula: C10H11ClN5O6P
- Molecular Weight: 363.65100
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
- Create Date: 2019-02-16 21:13:56
- Modify Date: 2024-01-12 15:16:25
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8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].
| Name | 8-chloro-camp |
|---|---|
| Synonyms |
8-chloroadenosine 3',5'-cyclic-monophosphate
Tocladesine 8-chloro-O3',O5'-hydroxyphosphoryl-adenosine 8-CL-CAMP MFCD00153938 8-chloro-cyclicadenosinemonophosphate 8-chlorocyclicamp 8-chloroadenosine 3',5'-monophosphate |
| Description | 8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1]. |
|---|---|
| Related Catalog | |
| In Vitro | 8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1]. |
| In Vivo | In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1]. |
| References |
| Density | 2.55 g/cm3 |
|---|---|
| Boiling Point | 731.7ºC |
| Molecular Formula | C10H11ClN5O6P |
| Molecular Weight | 363.65100 |
| Flash Point | 396.3ºC |
| Exact Mass | 363.01400 |
| PSA | 164.65000 |
| LogP | 0.41720 |
| Index of Refraction | 2.009 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |