81418-42-0

81418-42-0 structure

Name: 3-acetyl-5-methoxy-1,4-dihydronaphthoquinone
Chemical Name: 3-acetyl-5-methoxy-1,4-dihydronaphthoquinone
CAS Number: 81418-42-0
Molecular Formula: C₁₃H₁₀O₄
Molecular Weight: 230.21600
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2016-06-26 21:14:15
Modify Date: 2025-08-27 12:26:15
SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in drug discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19[1].

Name	3-acetyl-5-methoxy-1,4-dihydronaphthoquinone
Synonyms	3-Acetyl-5-methoxy-1,4-naphthoquinone 3-acetyl-5-methoxy-1,4-naphthoquinone 8-Methoxy-2-acetyl-naphthochinon-(1,4) 2-acetyl-8-methoxy-1,4-naphthoquinone

Description	SARS-CoV MPro-IN-2 (compound 15) is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 72.07 nM. The main protease (Mpro) of the virus as the major enzyme processing viral polyproteins contributes to the replication and transcription of SARS-CoV-2 in host cells, and has been characterized as an attractive target in drug discovery. SARS-CoV MPro-IN-2 has the potential for the research of COVID-19[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
References	[1]. Cui J, et al. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. Eur J Med Chem. 2021;225:113789.

Precursor 0
DownStream 3
481-74-3 3300-25-2 7414-92-8