52811-37-7
52811-37-7 structure
- Name: Cearoin
- Chemical Name: (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone
- CAS Number: 52811-37-7
- Molecular Formula: C14H12O4
- Molecular Weight: 244.24300
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-10-09 22:32:35
- Modify Date: 2025-08-23 16:27:30
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Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1].
| Name | (2,5-dihydroxy-4-methoxyphenyl)-phenylmethanone |
|---|
| Description | Cearoin, isolated from Dalbergia odorifera, increases autophagy and apoptosis through the production of ROS and the activation of ERK[1]. |
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| Related Catalog | |
| Target |
ERK ROS Autophagy Apoptosis |
| In Vitro | Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1]. Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1]. Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1]. Cell Viability Assay[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 1, 5, 10, 20, 40, or 80 μM Incubation Time: 6 or 12 hours Result: Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells. Western Blot Analysis[1] Cell Line: Human neuroblastoma SH-SY5Y cells Concentration: 0, 5, 10, 20, 40, or 80 μM Incubation Time: 12 hours Result: Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation. Induced the formation of LC3B-II in a dose dependent manner. |
| References |
| Density | 1.296g/cm3 |
|---|---|
| Boiling Point | 443.8ºC at 760 mmHg |
| Molecular Formula | C14H12O4 |
| Molecular Weight | 244.24300 |
| Flash Point | 171.7ºC |
| Exact Mass | 244.07400 |
| PSA | 66.76000 |
| LogP | 2.33740 |
| Index of Refraction | 1.623 |
| HS Code | 2914509090 |
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52811-37-7 |
| Literature: Kumar, Sarvesh; Reddy L, Chandra Shekhar; Kumar, Yogesh; Kumar, Amit; Singh, Brajendra K.; Kumar, Vineet; Malhotra, Shashwat; Pandey, Mukesh K.; Jain, Rajni; Thimmulappa, Rajesh; Sharma, Sunil K.; Prasad, Ashok K.; Biswal, Shyam; Van Der Eycken, Erik; Depass, Anthony L.; Malhotra, Sanjay V.; Ghosh, Balaram; Parmar, Virinder S. Archiv der Pharmazie, 2012 , vol. 345, # 5 p. 368 - 377 |
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| Literature: Laumas et al. Proceedings - Indian Academy of Sciences, Section A, 1957 , vol. 46, p. 343,346 |
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52811-37-7 |
| Literature: Kulshrestha,S.K. et al. Indian Journal of Chemistry, 1974 , vol. 12, p. 10 - 14 |
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52811-37-7 |
| Literature: Kulshrestha,S.K. et al. Indian Journal of Chemistry, 1974 , vol. 12, p. 10 - 14 |
| Precursor 4 | |
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| DownStream 0 | |
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |