495-61-4

495-61-4 structure

Name: β-Bisabolene
Chemical Name: (S)-β-bisabolene
CAS Number: 495-61-4
Molecular Formula: C₁₅H₂₄
Molecular Weight: 204.35100
Catalog: Signaling Pathways Others Others
Create Date: 2016-08-04 14:19:37
Modify Date: 2024-01-11 15:05:52
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer[1].

Name	(S)-β-bisabolene
Synonyms	nectadonhydrochloride coscopinhydrochloride longatinhydrochloride vadebexhydrochloride (S)-beta-bisabolene opianhydrochloride lyobexhydrochloride (4S)-1-Methyl-4-(6-methyl-1,5-heptadien-2-yl)cyclohexene capvalhydrochloride

Description	β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	β‐bisabolene exhibits selective cytotoxic activity for mouse cells, it against normal Eph4, MG1361 and 4T1 cells with IC50 values of >200 µg/ml, 65.49 µg/ml, and 48.99 µg/ml, respectively. It against normal MCF‐10A, MCF‐7, MDA‐MB‐231, SKBR3 and BT474 cells with IC50 values of 114.3 µg/ml, 66.91 µg/ml, 98.39 µg/ml, 70.62 µg/ml and 74.3 µg/ml, respectively[1].
In Vivo	β‐bisabolene is effective in reducing the growth of transplanted 4T1 mammary tumours in vivo (37.5% reduction in volume by endpoint)[1].
References	[1]. Syn Kok Yeo,et al. β-Bisabolene, a Sesquiterpene From the Essential Oil Extract of Opoponax (Commiphora Guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016 Mar;30(3):418-25.