1354235-96-3

1354235-96-3 structure

Name: trans-Ned 19
Chemical Name: (1R,3S)-1-(3-{[4-(2-Fluorophenyl)-1-piperazinyl]methyl}-4-methoxy phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid
CAS Number: 1354235-96-3
Molecular Formula: C₃₀H₃₁FN₄O₃
Molecular Weight: 514.59100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2016-10-30 16:18:20
Modify Date: 2025-08-26 01:37:59
trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].

Name	(1R,3S)-1-(3-{[4-(2-Fluorophenyl)-1-piperazinyl]methyl}-4-methoxy phenyl)-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid

Description	trans-Ned 19, a NAADP antagonist and TPC blocker, suppresses the calcium signal in human umbilical vein endothelial cells (HUVEC) and the rat aorta relaxation in response to low histamine concentrations[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	Ca2+
References	[1]. Zharkich IL, et al. Suppression of Histamine-Induced Relaxation of Rat Aorta and Calcium Signaling in Endothelial Cells by Two-Pore Channel Blocker trans-NED19 and Hydrogen Peroxide. Izv Akad Nauk Ser Biol. 2016 Jul;(4):430-438.