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Product Name: AAPTAMINE
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85547-22-4

85547-22-4 structure

85547-22-4 structure

Name: Aaptamine
Chemical Name: Aaptamine
CAS Number: 85547-22-4
Molecular Formula: C₁₃H₁₂N₂O₂
Molecular Weight: 228.24700
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2017-06-13 22:59:08
Modify Date: 2025-08-20 19:31:39
Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner[1][1].

Name	Aaptamine
Synonyms	8,9-dimethoxy-4h-benzo[de][1,6]naphthyridine UNII-FGW9D01COE 8,9-Dimethoxy-1H-benzo(de)(1,6)naphthyridine Aaaptamine Hydrochloride 1H-Benzo(de)(1,6)naphthyridine,8,9-dimethoxy

Description	Aaptamine, a spongean alkaloid isolated from a sea sponge Aaptos aaptos, is a competitive antagonist of α-adrenoceptor and activates the p21 promoter in a p53-independent manner[1][1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
References	[1]. Ohizumi Y, et al. Alpha-adrenoceptor blocking action of aaptamine, a novel marine natural product, in vascular smooth muscle. J Pharm Pharmacol. 1984 Nov;36(11):785-6. [2]. Aoki S, et al. Aaptamine, a spongean alkaloid, activates p21 promoter in a p53-independent manner. Biochem Biophys Res Commun. 2006 Mar 31;342(1):101-6.

Density	1.246g/cm3
Boiling Point	420.578ºC at 760 mmHg
Molecular Formula	C₁₃H₁₂N₂O₂
Molecular Weight	228.24700
Flash Point	208.158ºC
Exact Mass	228.09000
PSA	47.14000
LogP	2.73330
Index of Refraction	1.641

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DI2410500

CHEMICAL NAME :: 1H-Benzo(de)(1,6)naphthyridine, 8,9-dimethoxy-

CAS REGISTRY NUMBER :: 85547-22-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C13-H12-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 24(7),15,1990

HS Code	2933990090

Precursor 2
4602-73-7 3382-18-1
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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