880081-81-2

880081-81-2 structure

Name: m-PEG8-O-alkyne
Chemical Name: 2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne
CAS Number: 880081-81-2
Molecular Formula: C₂₀H₃₈O₉
Molecular Weight: 422.51000
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-04-30 09:30:20
Modify Date: 2025-09-13 20:47:11
m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne
Synonyms	mPEG8-CH2C≡CH

Description	m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.