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16836-31-0

16836-31-0 structure
16836-31-0 structure
  • Name: Kauran-16,17-diol (ent-Kauran-16beta,17-diol)
  • Chemical Name: Kauran-16,17-diol
  • CAS Number: 16836-31-0
  • Molecular Formula: C20H34O2
  • Molecular Weight: 306.48300
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2016-10-17 12:13:17
  • Modify Date: 2025-08-20 16:59:17
  • Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
Name Kauran-16,17-diol
Synonyms Ent-kauran-16,17-diol
Kaurane-16,17-diol
(5beta,9beta,10alpha,16beta)-Kaurane-16,17-Diol
Description Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].
Related Catalog
In Vitro Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].
References

[1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.

[2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.
Density 1.09g/cm3
Boiling Point 422.3ºC at 760mmHg
Molecular Formula C20H34O2
Molecular Weight 306.48300
Flash Point 186.8ºC
Exact Mass 306.25600
PSA 40.46000
LogP 4.14260
Vapour Pressure 6.7E-09mmHg at 25°C
Index of Refraction 1.55
Storage condition 2-8℃
14506-80-0 structure

14506-80-0

~%

16836-31-0 structure

16836-31-0

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921
42753-28-6 structure

42753-28-6

~%

16836-31-0 structure

16836-31-0

84678-18-2 structure

84678-18-2

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921
42753-28-6 structure

42753-28-6

~%

16836-31-0 structure

16836-31-0

Literature: Hanson,J.R. Journal of the Chemical Society, 1963 , p. 5061 - 5066
67-56-1 structure

67-56-1

42753-28-6 structure

42753-28-6

~%

16836-31-0 structure

16836-31-0

84678-18-2 structure

84678-18-2

Literature: Kitajima; Komori; Kawasaki Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 3912 - 3921
469-85-2 structure

469-85-2

~%

16836-31-0 structure

16836-31-0

Literature: Hanson,J.R. Journal of the Chemical Society, 1963 , p. 5061 - 5066
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