158364-59-1
158364-59-1 structure
- Name: Pumaprazole
- Chemical Name: methyl N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]carbamate
- CAS Number: 158364-59-1
- Molecular Formula: C19H22N4O2
- Molecular Weight: 338.40400
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Proton Pump
- Create Date: 2017-06-19 04:12:50
- Modify Date: 2024-01-21 01:00:00
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Pumaprazole is a reversible proton pump antagonist.
| Name | methyl N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]carbamate |
|---|---|
| Synonyms |
8-(2-methoxycarbonylamino-6-methylbenzylamino)-2,3-dimethylimidazo[1,2-a]pyridine
Pumaprazole Methyl 2-(((2,3-dimethylimidazo(1,2-a)pyridin-8-yl)amino)methyl)-3-methylcarbanilate Pumaprazole [INN] UNII-DK95Z519WL |
| Description | Pumaprazole is a reversible proton pump antagonist. |
|---|---|
| Related Catalog | |
| Target |
proton pump[1] |
| In Vivo | Pumaprazole is a reversible proton pump antagonist. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine. Pumaprazole displays identical ID50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23) and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect[1]. |
| Animal Admin | The pylorus of female Sprague-Dawley rats (160 to 220 g body weight) is ligated under ether anesthesia, the abdomen is closed and 100 mg/kg of acetylsalicylic acid (ASA) in 10 mL/kg are given orally. Following ASA administration, Pumaprazole (solution) or vehicle (i.v. saline or tap water in case of oral administration) is given i.v. in 1 mL/kg or i.d. in 2.5 mL/kg. Oral drug administration (in 10 mL/kg) is 1 h before pylorus ligation. Four hours after pylorus ligation, the stomach is excised, carefully keeping the esophagus closed, opened along the greater curvature and the luminal contents are removed, centrifuged, the volume is measured and the acidity determined by titration with 0.1 N NaOH to pH 7[1]. |
| References |
| Density | 1.21g/cm3 |
|---|---|
| Molecular Formula | C19H22N4O2 |
| Molecular Weight | 338.40400 |
| Exact Mass | 338.17400 |
| PSA | 71.15000 |
| LogP | 4.13650 |
| Index of Refraction | 1.615 |
| Storage condition | 2-8℃ |
|
~%
158364-59-1 |
| Literature: BYK Gulden Lomberg Chemische Fabrik GmbH Patent: US5665730 A1, 1997 ; |
