934660-94-3

934660-94-3 structure

Name: Cobimetinib (R-enantiomer)
Chemical Name: [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone
CAS Number: 934660-94-3
Molecular Formula: C₂₁H₂₁F₃IN₃O₂
Molecular Weight: 531.31000
Catalog: Research Areas Cancer
Create Date: 2016-08-22 03:56:52
Modify Date: 2025-08-22 21:15:44
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.

Name	[3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-[3-hydroxy-3-[(2R)-piperidin-2-yl]azetidin-1-yl]methanone
Synonyms	1-({3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}carbonyl)-3-[(2R)-piperidin-2-yl]azetidin-3-ol Cobimetinib (R-enantiomer) (R)-XL518 GDC-0973 R-enantiomer CS-1022

Description	Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor.
Related Catalog	Research Areas >> Cancer
References	[1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.