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Product Name: H-HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE-OH
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131334-43-5

131334-43-5 structure

Name: Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt
Chemical Name: h-his-cys-leu-gly-lys-trp-leu-gly-his-pro-asp-lys-phe-oh
CAS Number: 131334-43-5
Molecular Formula: C₇₂H₁₀₄N₂₀O₁₆S
Molecular Weight: 1537.79000
Catalog: Peptides
Create Date: 2018-11-28 18:44:53
Modify Date: 2024-01-11 13:01:40
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).

Name	h-his-cys-leu-gly-lys-trp-leu-gly-his-pro-asp-lys-phe-oh
Synonyms	LIPOPHILIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) MYELIN PROTEOLIPID PROTEIN (139-151) Myelin Proteolipid Protein (139-151) (1) MYELIN PROTEOLIPID PROTEIN (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) PLP (139-151) (DEPALMITOYLATED) (HUMAN,BOVINE,DOG,MOUSE,RAT) PLP (HUMAN,BOVINE,DOG,MOUSE,RAT) HIS-CYS-LEU-GLY-LYS-TRP-LEU-GLY-HIS-PRO-ASP-LYS-PHE MYELIN PROTEOLIPID PROTEIN (139-151) (HUMAN,BOVINE,DOG,MOUSE,RAT) PLP (139-151)

Description	PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE).
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Peptides
In Vitro	Severe clinical and histological EAE could be induced by adoptive transfer of the peptide-specific T cell line and 3 of 4 T cell clones. The T cell line/clones all responded strongly to PLP (139-151) in in vitro proliferative assays. Line SPL and all of the clones show strong proliferative response to the whole PLP molecule and to PLP (139-151)[1].
In Vivo	PLP (139-151) induces acute experimental allergic encephalomyelitis (EAE) in SJL/J mice. Beginning on Day 9, the mice treated with PLP (139-151) show signs of EAE and the disease progressed rapidly to paralysis. Central nervous system inflammation, edema, gliosis, and demyelination are found in all mice killed between Days 10 and 28[2]. Young male SJL mice immunized with a major encephalitogenic peptide of myelin, PLP 139-151, develop initial clinical and histological symptoms of EAE with a severity similar to age-matched females; however, unlike females, male mice does not relapse. Significant T cell proliferation to PLP 139-151, but not to other PLP and myelin basic protein (MBP) epitopes, is observed in both males and females during the initial episode, recovery, and first relapse of clinical disease[3].
References	[1]. Kuchroo VK, et al. Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 1991;59(5):305-12. [2]. Sobel RA, et al. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide ofmyelin proteolipid protein. J Neuropathol Exp Neurol. 1990 Sep;49(5):468-79. [3]. Bebo BF Jr, et al. Male SJL mice do not relapse after induction of EAE with PLP 139-151. J Neurosci Res. 1996 Sep 15;45(6):680-9.

Molecular Formula	C₇₂H₁₀₄N₂₀O₁₆S
Molecular Weight	1537.79000
Exact Mass	1536.77000
PSA	605.02000
LogP	3.97660
Storage condition	2-8℃

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