926281-37-0
926281-37-0 structure
- Name: GGsTop
- Chemical Name: Benzeneacetic acid, 3-[[(3-amino-3-carboxypropyl)methoxyphosphinyl]oxy]
- CAS Number: 926281-37-0
- Molecular Formula: C13H18NO7P
- Molecular Weight: 331.26
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2016-12-24 12:47:17
- Modify Date: 2025-08-26 11:16:29
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GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively[1][2]. GGsTop protects hepatic ischemia-reperfusion injury in rat model[3].
| Name | Benzeneacetic acid, 3-[[(3-amino-3-carboxypropyl)methoxyphosphinyl]oxy] |
|---|---|
| Synonyms |
Benzeneacetic acid, 3-[[(3-amino-3-carboxypropyl)methoxyphosphinyl]oxy]-
2-Amino-4-{[3-(carboxymethyl)phenoxy](methoxy)phosphoryl}butanoic acid |
| Description | GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT. GGsTop shows a pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively[1][2]. GGsTop protects hepatic ischemia-reperfusion injury in rat model[3]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 170 μM (Human GGT)[1] |
| In Vitro | GGsTop (Nahlsgen; Compound 5a) is a potent, highly selective and irreversible γ−glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT[1]. GGsTop shows pKa of 9.71, also exhibits Kons of 150±10 and 51±3 M-1 s-1 against E.coli GGT and human GGT, respectively[1][2]. GGsTop is non-toxic compound, completely inhibits WT human GGT in 1 min at 1 mM, but less potent against the K562S mutant[2]. |
| In Vivo | GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats[3]. GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats[3]. Animal Model: Male rats (9 week old)[3] Dosage: 1 mg/kg Administration: Injected into the inferior vena cava for 12, 24, 48 h Result: Lowered the serum levels of ALT, AST, prevented the increase of serum γ-GT levels in IR-GGsTop group. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 557.7±50.0 °C at 760 mmHg |
| Molecular Formula | C13H18NO7P |
| Molecular Weight | 331.26 |
| Flash Point | 291.1±30.1 °C |
| Exact Mass | 331.082092 |
| PSA | 145.96000 |
| LogP | -0.66 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.559 |
| Storage condition | -20°C |