Wnt/β-catenin agonist 3

Wnt/β-catenin agonist 3 (compound 98) is a Wnt/β-catenin signalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis[1].

Research Areas >> Cardiovascular Disease

Wnt/β-catenin agonist 3 (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM)[1]. Wnt/β-catenin agonist 3 (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin[1]. Wnt/β-catenin agonist 3 (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition[1]. Western Blot Analysis[1] Cell Line: HEK293 cells Concentration: 30 and 60 μM Incubation Time: 24 hours Result: Deposited β-catenin in a dose-dependent pattern within cells.

[1]. Cho JW, et al. Isoxazole derivatives and use thereof. WO2007078113A1.