Gambogic acid B

Names

[ Name ]:
Gambogic acid B

[Synonym ]:
2-Butenoic acid, 4-[(1R,3aS,5S,6S,6aS,11R,14aS)-6-ethoxy-3a,4,5,6,6a,7-hexahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-, (2Z)-
(2Z)-4-[(1S,2S,8R,15S,16S,17S,19R)-16-Ethoxy-12-hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11 ]docosa-4(13),5,9,11-tetraen-19-yl]-2-methyl-2-butenoic acid

Biological Activity

[Description]:

Gambogic acid B is an active compound. Gambogic acid B can be isolated from the resin of Garcinia hanburyi.. Gambogic acid B has cytotoxicity against A549, HCT116 and MDA‑MB‑231 cells with IC50 values of 1.60 μM, 6.88 μM and 0.87 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: 1.60 μM (A549 cell); 6.88 μM (HCT116 cell); 0.87 μM (MDA‑MB‑231 cell)[1]

[In Vitro]

Gambogic acid B 对 A549、HCT116 和 MDA-MB-231 细胞具有细胞毒性， IC50 值分别为 1.60 μM、6.88 μM 和 0.87 μM[1]。

[References]

[1]. Deng, Yun-Xia et al. Three new xanthones from the resin of Garcinia hanburyi. Planta medica vol. 79,9 (2013): 792-6.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
815.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄₀H₅₀O₉

[ Molecular Weight ]:
674.820

[ Flash Point ]:
247.5±27.8 °C

[ Exact Mass ]:
674.345459

[ LogP ]:
11.27

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.606

Related Compounds

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