PD 90780

Names

[ CAS No. ]:
77422-99-2

[ Name ]:
PD 90780

[Synonym ]:
7-(benzoylamino)-4,9-dihydro-4-methyl-9-oxopyrazolo[5,1-b]quinazoline-2-carboxylic acid
7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo[5,1-b]quinazoline-2-carboxylic acid
7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxopyrazolo-[5,1-b]quinazoline-2-carboxylic acid

Biological Activity

[Description]:

PD 90780 is a non peptide antagonist of nerve growth factor (NGF) binding to the P75 NGF receptor, inhibits NGF-p75 NTR interaction with IC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively [1] .

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

IC50: 23.1 µM (NGF, PC12 cells), 1.8 µM (NGF, PC12 nnr5 cells)


[References]

[1]. Colquhoun A , et al. Differential activity of the nerve growth factor (NGF) antagonist PD90780 [7-(benzolylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid] suggests altered NGF-p75NTR interactions in the presence of TrkA. J Pharmacol Exp Ther. 2004 Aug;310(2):505-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H14N4O4

[ Molecular Weight ]:
362.34

[ Exact Mass ]:
362.10200

[ PSA ]:
105.70000

[ LogP ]:
2.20970

Related Compounds