LB-60-OF61 hydrochloride

Names

[ CAS No. ]:
742064-38-6

[ Name ]:
LB-60-OF61 hydrochloride

Biological Activity

[Description]:

LB-60-OF61 hydrochloride is a potent NAMPT (nicotinamide phosphoribosyltransferase) inhibitor. LB-60-OF61 hydrochloride is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Nampt

[In Vitro]

LB-60-OF61 is potent against HCT116 cells with an IC50 around 30 nM as measured in a 384 well format[1].

[References]

[1]. Estoppey D, et al. Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Sci Rep. 2017;7:42728. Published 2017 Feb 16.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H31ClN6O2

[ Molecular Weight ]:
531.05

Related Compounds