ABT-670

Names

[ CAS No. ]:
630119-43-6

[ Name ]:
ABT-670

[Synonym ]:
2-(1-{[(3-methylbenzoyl)amino]methyl}-4-piperidinyl)pyridinium N-oxide
UNII-4L6071XH2J
Benzamide,3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl]
ABT-670

Biological Activity

[Description]:

ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Others

[Target]

EC50: 89 nM (Human D4), 160 nM (Ferret D4), 93 nM (Rat D4)[1]


[In Vitro]

ABT-670 is a selective D4 agonist, with EC50 of 89 nM, 160 nM, and 93 nM for human D4, ferret D4, and rat D4, respectively[1].

[In Vivo]

ABT-670 (0.1 μmol/kg) robustly induces a high (75%) incidence of erections in male rats. ABT-670 exhibits excellent oral bioavailability in rat, dog, and monkey (68%, 85%, and 91%, respectively) with comparable efficacy, safety, and tolerability[1].

[References]

[1]. Patel MV, et al. Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction. J Med Chem. 2006 Dec 14;49(25):7450-65.


[Related Small Molecules]

CB-154 mesylate | SCH 23390 hydrochloride | Levodopa | Cabergoline | Thioridazine hydrochloride | Brexpiprazole | Domperidone | Trifluoperazine dihydrochloride | pimozide | Risperidone | SKF38393 HCl | Cariprazine | SERTINDOLE | Fluphenazine (dihydrochloride) | Nomifensine

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23N3O2

[ Molecular Weight ]:
325.40500

[ Exact Mass ]:
325.17900

[ PSA ]:
61.29000

[ LogP ]:
3.50310

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Related Compounds