2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride
Names
[ CAS No. ]:
411208-45-2
[ Name ]:
2-[2-[(dimethylamino)methyl]phenyl]sulfanyl-5-methylaniline,dihydrochloride
[Synonym ]:
dihydrochloride
2-(2'-Amino-4'-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
2-(2 inverted exclamation marka-Amino-4 inverted exclamation marka-methylphenylthio)-N,N-dimethylbenzylamine dihydrochloride
N,N-dimethyl-2-(2-amino-4-methylphenylthio)benzylamine
MADAM dihydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
426.4ºC at 760 mmHg
[ Molecular Formula ]:
C16H22Cl2N2S
[ Molecular Weight ]:
345.33000
[ Flash Point ]:
211.7ºC
[ Exact Mass ]:
344.08800
[ PSA ]:
54.56000
[ LogP ]:
5.97520
MSDS
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
J. Med. Chem. 45 , 1253-1258, (2002)
A series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (SERT), and norepineph...
Pharmacological characterization of N,N-dimethyl-2-(2-amino-4-methylphenyl thio)benzylamine as a ligand of the serotonin transporter with high affinity and selectivity.J. Pharmacol. Exp. Ther. 304 , 81-87, (2003)
Serotonin transporter has a key-role in regulation of serotoninergic function, and is involved in numerous neurodegenerative and psychiatric disorders. To obtain an efficient radioactive ligand allowi...