Methylmercaptophos oxide
Names
[ CAS No. ]:
301-12-2
[ Name ]:
Methylmercaptophos oxide
[Synonym ]:
Oxydemetonmethyl
EINECS 206-110-7
Metaisosystox sulfoxide
Metasystemox R
thiophosphoric acid S-(2-ethanesulfinyl-ethyl) ester O,O'-dimethyl ester
Methylmercaptophos oxide
Demeton-O-methyl sulfoxide
Methyl demeton-O-sulfoxide
O,O-dimethyl S-<2-(ethylsulfinyl)ethyl>phosphorothioate
S-[2-(Ethylsulfinyl)ethyl] O,O-dimethyl phosphorothioate
S-2-Ethylsulfinylethyl O,O-dimethyl phosphorothioate
Metasystox-R
OS2&2SPO&O1&O1
Aimco systox
Phosphorothioic acid, S-[2-(ethylsulfinyl)ethyl] O,O-dimethyl ester
Methyl oxydemeton S
Metasystemox
S-[2-(ethanesulfinyl)ethyl] O,O-dimethyl phosphorothioate
PO-methylsystox-sulfoxide
S-[2-(Ethylsulfinyl)ethyl]-O,O-dimethylthiophosphat
1-dimethoxyphosphorylsulfanyl-2-ethylsulfinylethane
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
377.6±44.0 °C at 760 mmHg
[ Melting Point ]:
<-20ºC
[ Molecular Formula ]:
C6H15O4PS2
[ Molecular Weight ]:
246.285
[ Flash Point ]:
182.2±28.4 °C
[ Exact Mass ]:
246.014938
[ PSA ]:
106.92000
[ LogP ]:
-0.74
[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C
[ Index of Refraction ]:
1.519
[ Storage condition ]:
0-6°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TG1420000
- CHEMICAL NAME :
- Phosphorothioic acid, S-(2-(ethylsulfinyl)ethyl) O,O-dimethyl ester
- CAS REGISTRY NUMBER :
- 301-12-2
- BEILSTEIN REFERENCE NO. :
- 1711268
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 30
- MOLECULAR FORMULA :
- C6-H15-O4-P-S2
- MOLECULAR WEIGHT :
- 246.30
- WISWESSER LINE NOTATION :
- OS2&2SPO&O1&O1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1500 mg/m3/1H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - pigeon
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - quail
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - duck
- DOSE/DURATION :
- 54 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - wild bird species
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Bird - chicken
- DOSE/DURATION :
- 490 mg/kg/1W-C
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 40 mg/L
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,621,1982 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83049 No. of Facilities: 110 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 254 (estimated)
Safety Information
[ Symbol ]:
GHS06, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301 + H311-H400
[ Precautionary Statements ]:
P273-P280-P301 + P310-P312
[ Hazard Codes ]:
T: Toxic;N: Dangerous for the environment;
[ Risk Phrases ]:
24/25-50
[ Safety Phrases ]:
S23-S36/37-S45-S61
[ RIDADR ]:
UN 2810 6.1/PG 2
[ RTECS ]:
TG1420000
[ Packaging Group ]:
II
[ HS Code ]:
2930909061
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909061
[ Summary ]:
2930909061 o,o,o',o'-tetramethyl o,o'-(thiobis(4,1-phenylene)) diphosphorothioate。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%
Articles
Environ. Monit. Assess. 186(7) , 3995-9, (2014)
Pesticides are considered as the most polluting substances. The residue of pesticides in agricultural crops, especially in greenhouse harvests, has been reported critical. Cucumber, considered as a ve...
Determination of polar organophosphorus pesticides in water samples by hydrophilic interaction liquid chromatography with tandem mass spectrometry.Rapid Commun. Mass Spectrom. 22(14) , 2203-10, (2008)
A method combining hydrophilic interaction liquid chromatography (HILIC) with tandem mass spectrometry (MS/MS) was developed for the determination of polar organophosphorus pesticides (OPPs; acephate,...
Committee on Pesticides and Disinfectant Formulations. Pesticide formulations: CIPAC studies. Collaborative International Pesticide Analytical Council.J. AOAC Int. 85(1) , 249-51, (2002)