Radotinib-d6

Names

[ CAS No. ]:
2754051-83-5

[ Name ]:
Radotinib-d6

Biological Activity

[Description]:

Radotinib-d6 is deuterium labeled Radotinib.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Bcr-Abl

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Kim SH, et al. Efficacy and safety of radotinib in chronic phase chronic myeloid leukemia patients with resistance or intolerance to BCR-ABL1 tyrosine kinase inhibitors. Haematologica. 2014 Jul;99(7):1191-6.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₁₅D₆F₃N₈O

[ Molecular Weight ]:
536.54

Related Compounds

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