IRAK4-IN-9

Names

[ CAS No. ]:
2681278-07-7

[ Name ]:
IRAK4-IN-9

Biological Activity

[Description]:

IRAK4-IN-9 (compound 73) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-9 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> IRAK
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> IRAK

[Target]

IRAK4:1.5 nM (IC50)


[References]

[1]. Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13(3):336-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H25N7

[ Molecular Weight ]:
387.48

Related Compounds