Axl-IN-6

Names

[ Name ]:
Axl-IN-6

Biological Activity

[Description]:

Axl-IN-6 (compound 14) is an orally active and potent AXL inhibitor. Axl-IN-6 is well tolerated and significantly inhibits the tumor growth in MV-4-11 subcutaneous xenograft model[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> TAM Receptor

[Target]

AXL[1]

[References]

[1]. Zhang LL, et al. Discovery a series of quinazolin derivatives as potent AXL inhibitors. Eur J Med Chem. 2022 Apr 6;237:114316.[published online ahead of print, 2022 Apr 6]. Eur J Med Chem. 2022;237:114316.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₆N₄O

[ Molecular Weight ]:
492.65

Related Compounds

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