hCAIX-IN-11

Names

[ Name ]:
hCAIX-IN-11

Biological Activity

[Description]:

hCAIX-IN-11 (Compound 5d) is a selective carbonic anhydrase IX and XII inhibitor with Ki s of 32.7 and 623.5 nM for hCA IX and hCA XII, respectively. hCA IX and hCA XII are transmembrane isoforms which have been characterized as biomarkers for several types of tumors. The hCA XII assists in maintenance of acid-base homoeostasis in normal as well as tumor cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Carbonic Anhydrase

[Target]

Ki: 32.7 nM (hCA IX), 623.5 nM (hCA XII), ＞10000 nM nM (hCA I), ＞10000 (hCA II)[1]

[References]

[1]. Pavitra S Thacker,et al. Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors. Bioorg Chem. 2020 Nov;104:104272.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₅ClN₄O₃

[ Molecular Weight ]:
406.82

Related Compounds

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