DKFZ-748

DKFZ-748 is a selective HDAC10 inhibitor (pIC50=7.66), and shows anti-tumor activity[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

DKFZ-748 shows dose-dependent growth inhibition of HeLa cells in a polyamine-limiting in vitro tumor model[1]. DKFZ-748 (1-100 μM; 72 h) induces acetylation of BE(2)-C cells[1]. DKFZ 748 shows significant accumulation of N8 acetyl- and N1,8-diacetylspermidine in a dose-dependent manner[1]. Western Blot Analysis[1] Cell Line: BE(2)-C cells Concentration: 1, 10, 100 μM Incubation Time: 72 h Result: Induced significant acetylation only at the highest tested concentration (100 μM).

[1]. Steimbach RR, et al. Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. J Am Chem Soc. 2022 Oct 19;144(41):18861-18875.