Indirubin-5-sulfonate

Names

[ CAS No. ]:
244021-67-8

[ Name ]:
Indirubin-5-sulfonate

Biological Activity

[Description]:

Indirubin-5-sulfonate is a cyclin-dependent kinase (CDK) inhibitor, with IC50 values of 55 nM, 35 nM, 150 nM, 300 nM and 65 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1, and CDK5/p35, respectively[1]. Indirubin-5-sulfonate also shows inhibitory activity against GSK-3β[2].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

Cdk1/cyclin B:55 nM (IC50)

cdk2/cyclin A:35 nM (IC50)

CDK2/cyclinE:150 nM (IC50)

Cdk4/cyclin D1:300 nM (IC50)

CDK5/p35:65 nM (IC50)

GSK-3β


[References]

[1]. Hoessel R, et al. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol. 1999 May;1(1):60-7.

[2]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H10N2O5S

[ Molecular Weight ]:
342.33

Related Compounds