HBV-IN-30

Names

[ CAS No. ]:
2413192-92-2

[ Name ]:
HBV-IN-30

Biological Activity

[Description]:

HBV-IN-30 (ex44), a flavone derivative, is a potent covalently closed circular DNA (cccDNA) inhibitor. cccDNA serves as the template for viral RNA transcription and subsequent viral DNA generation. HBV-IN-30 has the potential for the research of HBV infection[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> HBV

[In Vitro]

HBV-IN-30 (ex44; 24 h) 在 HepDES19 细胞中抑制 HBeAg 水平和细胞活力，IC50 值为 0.57 μM。HepDES19 是产生 cccDNA 的细胞系[1]。 HBV-IN-30 (5 天) 以剂量依赖性方式降低 HepDES19 细胞中的 cccDNA 水平[1]。 HBV-IN-30 (9 天; 原代人肝细胞 (PHH)) 具有抗 HBV 作用并抑制 HBeAg，IC50 值为 0.04 μM[1]。

[References]

[1]. Song F, et, al. Flavone compounds for the treatment and prophylaxis of hepatitis b virus disease. WO2020053249.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18BrClO6

[ Molecular Weight ]:
493.73

Related Compounds