RAF mutant-IN-1

Names

[ CAS No. ]:
2340020-82-6

[ Name ]:
RAF mutant-IN-1

Biological Activity

[Description]:

RAF mutant-IN-1 is a RAF kinase inhibitor, extracted from patent WO2019107987A1, with IC50 values of 21 nM, 30 nM and 392 nM for C-RAF 340D/Y341D, B-RAFV600E and B-RAFWT, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

C-RAF 340D/Y341D:21 nM (IC50)

B-RafV600E:30 nM (IC50)

BRAFWT:392 nM (IC50)


[References]

[1]. BAE, In Hwan, et al. Title of Invention: THIENO[3,2-d]PYRIMIDINE COMPOUND HA VING INHIBITORY ACTIVITY FOR PROTEIN KINASE. WO2019107987A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H18Cl3FN6O2S

[ Molecular Weight ]:
567.85

Related Compounds