GNE-9278
Names
[ CAS No. ]:
2315311-83-0
[ Name ]:
GNE-9278
Biological Activity
[Description]:
GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].
[Related Catalog]:
[Target]
NMDAR[1]
[In Vitro]
GNE-9278 (50 μM) slows deactivation with multiple agonists (D-Glu, L-Glu and L-CCG-IV) and enhances the potency of both Glu and Gly[1]. GNE-9278 robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs as measured by calcium influx assays from HEK cell lines with the EC50s of 0.74, 3.07, 0.47, and 0.32 μM, respectively[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C21H27N5O3S
[ Molecular Weight ]:
429.54