URAT1 inhibitor 1

Names

[ CAS No. ]:
2268720-62-1

[ Name ]:
URAT1 inhibitor 1

Biological Activity

[Description]:

URAT1 inhibitor 1 (1g) is a uric acid transporter 1 (URAT1) inhibitor, with an IC50 of 32 nM. URAT1 inhibitor 1 has potential to treat hyperuricemia associated with gout[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> URAT1
Research Areas >> Inflammation/Immunology

[Target]

IC50: 32 nM (URAT1)[1].


[References]

[1]. Wu JW, et al. Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout. Bioorg Med Chem Lett. 2019 Feb 1;29(3):383-388.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H15Br2N5O2S2

[ Molecular Weight ]:
569.29

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds