Fenoldopam hydrochloride

Names

[ CAS No. ]:
181217-39-0

[ Name ]:
Fenoldopam hydrochloride

[Synonym ]:
9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol,hydrochloride

Biological Activity

[Description]:

Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Signaling Pathways >> Epigenetics >> Histone Demethylase
Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

[Target]

IC50: 0.8974 μM (LSD1)[2]


[References]

[1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8.  

[2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.  

[3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H17Cl2NO3

[ Molecular Weight ]:
342.22

[ Exact Mass ]:
341.05900

[ PSA ]:
72.72000

[ LogP ]:
3.86520

Related Compounds