Pristane-d40

Names

[ CAS No. ]:
16416-35-6

[ Name ]:
Pristane-d40

[Synonym ]:
Pristan-1-ol
1-Pentadecanol,2,6,10,14-tetramethyl
norphytanol
Pristan-d40
2H,6H,10H,14H-octacosadeuterio-2,6,10,14-tetrakis-trideuteriomethyl-pentadecane
2,6,10,14-tetramethyl-pentadecan-1-ol

Biological Activity

[Description]:

Pristane-d40 is the deuterium labeled Pristane[1]. Pristane (Norphytane) is a naturally occurring hydrocarbon oil found in small quantities in many plants, in various marine organisms, and as the most active component of mineral oil[2]. Pristane is a non-antigenic adjuvant, and induces MHC class II-restricted, arthritogenic T cells in the rat[3].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. J J Turner, et al. Krypton Fluoride: Preparation by the Matrix Isolation Technique. Science. 1963 May 31;140(3570):974-5.  

[3]. Jens Holmberg,et al. Pristane, a non-antigenic adjuvant, induces MHC class II-restricted, arthritogenic T cells in the rat. J Immunol. 2006 Jan 15176(2):1172-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19D40

[ Molecular Weight ]:
308.76700

[ Exact Mass ]:
308.56400

[ LogP ]:
7.08150

Related Compounds