Win-62005

Names

[ CAS No. ]:
152633-54-0

[ Name ]:
Win-62005

[Synonym ]:
2H-Imidazo(4,5-b)pyridin-2-one,1,3-dihydro-5-methyl-6-(4-pyridinyl)
5-Methyl-6-(4-pyridinyl)-2H-imidazo(4,5-b)pyridin-2-one
Win-62005

Biological Activity

[Description]:

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Cardiovascular Disease

[Target]

Ki: 25 nM (PDE III), 25 nM (PDE III)[1]


[In Vitro]

Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].

[In Vivo]

After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].

[References]

[1]. Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25(1):14-21.


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.292g/cm3

[ Boiling Point ]:
291.8ºC at 760 mmHg

[ Molecular Formula ]:
C12H10N4O

[ Molecular Weight ]:
226.23400

[ Flash Point ]:
130.3ºC

[ Exact Mass ]:
226.08500

[ PSA ]:
74.69000

[ LogP ]:
2.03390

[ Vapour Pressure ]:
0.00191mmHg at 25°C

[ Index of Refraction ]:
1.621

[ Storage condition ]:
2-8℃

Related Compounds