Cyclophilin inhibitor 1

Names

[ CAS No. ]:
1509904-96-4

[ Name ]:
Cyclophilin inhibitor 1

Biological Activity

[Description]:

Cyclophilin inhibitor 1 is a potent and orally bioavailable cyclophilin A inhibitor, with a Kd of 5 nM, shows effective anti-HCV activity, with an EC50 of 98 nM for HCV 2a[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[Target]

Kd: 5 nM (Cyclophilin A)[1] EC50: 98 nM (HCV 2a)[1]


[In Vitro]

Cyclophilin inhibitor 1 (Compound 3) inhibits HCV 2a activity, with an EC50 of 98 nM[1].

[References]

[1]. Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8;61(21):9473-9499.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H39N5O7

[ Molecular Weight ]:
593.67

Related Compounds