Niraparib metabolite M1

Names

[ CAS No. ]:
1476777-06-6

[ Name ]:
Niraparib metabolite M1

[Synonym ]:
2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxylic acid
2H-Indazole-7-carboxylic acid, 2-[4-[(3S)-3-piperidinyl]phenyl]-

Biological Activity

[Description]:

Niraparib metabolite M1 is a metabolite of niraparib, and the latter one acts as a novel poly(ADP-Ribose) polymerase (PARP) inhibitor.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Others

[In Vitro]

Niraparib metabolite M1 has the validation in plasma and urine for the support of clinical studies such as the mass balance study and the absolute bioavailability study[1].

[References]

[1]. van Andel L, et al. Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Nov 19;1040:14-21.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
442.0±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H19N3O2

[ Molecular Weight ]:
321.373

[ Flash Point ]:
221.1±28.7 °C

[ Exact Mass ]:
321.147736

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.693

[ Storage condition ]:
2-8℃

Related Compounds