Nalidixic Acid-d5

Names

[ CAS No. ]:
1189467-36-4

[ Name ]:
Nalidixic Acid-d5

Biological Activity

[Description]:

Nalidixic Acid-d5 is the deuterium labeled Nalidixic acid. Nalidixic acid, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. antibiotic, DNA gyrase, susceptible bacteria, Escherichia coli, Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp, Salmonella spp.

[3]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol

Chemical & Physical Properties

[ Melting Point ]:
229-230°C

[ Molecular Formula ]:
C12H12N2O3

[ Molecular Weight ]:
232.23528

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-42/43

[ Safety Phrases ]:
22-36/37-45

[ RIDADR ]:
NONH for all modes of transport

Related Compounds