Philanthotoxin 343

[ Molecular Formula ]:
C₂₃H₄₁N₅O₃

[ Molecular Weight ]:
435.60300

[ Exact Mass ]:
435.32100

[ PSA ]:
128.51000

[ LogP ]:
3.29800

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors

Eur. J. Pharmacol. 686(1-3) , 22-31, (2012)

The GluN3 subunits of the N-methyl-d-aspartate (NMDA) receptor are known to reduce its Ca2+ permeability and Mg2+ sensitivity, however, little is known about their effects on other channel blockers. c...

Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.

J. Med. Chem. 39(2) , 515-21, (1996)

Acid-base properties (pKa values and proton distribution patterns) of philanthotoxin-343(PhTX-343) were investigated by 1H and 13C NMR titration. Chemical shift data and the total ionization shifts we...

A sequential high-yielding large-scale solution-method for synthesis of philanthotoxin analogues.

Eur. J. Med. Chem. 38(1) , 117-22, (2003)

A general, improved procedure for rapid synthesis of philanthotoxin analogues, a pharmacologically important class of polyamine conjugates, is described. The solution-phase procedure is illustrated by...

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