Hypocretin (70-98) (human)

Names

[ Name ]:
Hypocretin (70-98) (human)

[Synonym ]:
L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methionylglycine
MFCD09264725
Glycine, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methionyl-

Biological Activity

[Description]:

Hypocretin (70-98), human is a polypeptide that is capable of binding to an orexin receptor OX1R and promotes Apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Orexin Receptor (OX Receptor)

[Target]

human OX1R

[In Vitro]

Hypocretin (70-98), human 促进表达食欲素受体的细胞凋亡。 OX1R 促进癌细胞凋亡的机制与 Gq 介导的磷脂酶 C 激活和细胞钙瞬变无关。

[References]

[1]. Bruno Robert, et al. Polypeptides for preparing drug conjugates capable of promoting apoptosis in a cell expressing an orexin receptor. Patent WO2017140845A1.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₁₂₅H₂₁₄N₄₄O₃₇S

[ Molecular Weight ]:
2957.374

[ Exact Mass ]:
2955.593750

[ LogP ]:
-9.09

[ Index of Refraction ]:
1.665

Related Compounds

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