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(Val5)-Angiotensin II

Names

[ CAS No. ]:
58-49-1

[ Name ]:
(Val5)-Angiotensin II

[Synonym ]:
DRVYVHPF
(5-L-Val)-Angiotensin II
Angiotensin Acetate
L-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
<Val5>-angiotensin II
ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE
[Asp(1),Val(5)]angiotensin II
H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH
[VAL5] ANGIOTENSIN II HUMAN
ANGIOTENSIN II,5-L-VALINE
[val5]-angiotensin ii acetate hydrate
Asp-Arg-Val-Tyr-Val-His-Pro-Phe-OH
Angiotensin II 5-valine

Biological Activity

[Description]:

Angiotensin II 5-valine is an agonist of angiotensin receptor.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Research Areas >> Cancer
Peptides

[Target]

Angiotensin receptor[1].


[In Vivo]

By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone[1].

[Animal admin]

Rats[1] Male Sprague Dawley rats are uninephrectomized and divided into three groups: control (n=6), Angiotensin II 5-valine (exogenous form) infused (n=8), and Angiotensin II 5-valine infused rats treat with losartan (n=8). Angiotensin II 5-valine, which has the same biological and immunoreactive properties as endogenous ANG II, was infused at 40 ng/min via an osmotic minipump implant subcutaneously[1].

[References]

[1]. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8.


[Related Small Molecules]

Angiotensin II acetate salt | AVE 0991 | A 779 | Tranilast | PD123319 di(trifluoroacetate) | Telmisartan | Angiotensin II Receptor Ligand | Sacubitril/valsartan (LCZ696) | EMA401 | Fimasartan | RE 201 | C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt | BIBS 39

Chemical & Physical Properties

[ Molecular Formula ]:
C49H69N13O12

[ Molecular Weight ]:
1032.15

[ PSA ]:
443.64000

[ LogP ]:
2.77030

[ Storage condition ]:
-20°C

Related Compounds