Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt

Names

[ CAS No. ]:
217099-14-4

[ Name ]:
Cyclo(-Arg-Gly-Asp-D-Tyr-Lys) trifluoroacetate salt

[Synonym ]:
CYCLO (RGDYK)

[Description]:

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cytoskeleton >> Integrin

[Target]

IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]

[In Vitro]

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].

[References]

[ Molecular Formula ]:
C₂₇H₄₁N₉O₈

[ Molecular Weight ]:
619.67