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(Sar1,Ile8)-Angiotensin II

Names

[ CAS No. ]:
37827-06-8

[ Name ]:
(Sar1,Ile8)-Angiotensin II

[Synonym ]:
Sarile
N-Methylglycyl-N-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine
<Sar1,Ile5,Ile8>-angiotensin II
<Sar1-Ile8>-angiotensin II
SARILESIN
N-methylglycyl-N-(diaminomethylidene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-isoleucine
L-isoleucine, N-methylglycyl-N-(diaminomethylene)-L-ornithyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-
Angiotensin II [Sar1 Ile8]
[Sar1, Ile8]-Angiotensin II

Biological Activity

[Description]:

[Sar1, Ile8]-Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
Peptides
Research Areas >> Cardiovascular Disease

[In Vitro]

Angiotensin II has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. Angiotensin II activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells[1].

[References]

[1]. Griendling KK, et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res. 1994 Jun;74(6):1141-8.


[Related Small Molecules]

Angiotensin II acetate salt | AVE 0991 | A 779 | Tranilast | PD123319 di(trifluoroacetate) | Telmisartan | Angiotensin II Receptor Ligand | Sacubitril/valsartan (LCZ696) | EMA401 | Fimasartan | (Val5)-Angiotensin II | RE 201 | C-Type Natriuretic Peptide (32-53) (human, porcine, rat) acetate salt

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C46H73N13O10

[ Molecular Weight ]:
968.153

[ Exact Mass ]:
967.560364

[ PSA ]:
355.05000

[ LogP ]:
1.67

[ Index of Refraction ]:
1.638

Related Compounds