Thymic Factor trifluoroacetate salt

Names

[ Name ]:
Thymic Factor trifluoroacetate salt

[Synonym ]:
pyroglutamyl-alanyl-lysyl-seryl-glutaminyl-glycyl-glycyl-seryl-asparagine
Pyr-Ala-Lys-Ser-Asn-Gly-Gly-Ser-Gln
Nonathymulin
pyro-Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
THYMIC FACTOR
PYR-ALA-LYS-SER-GLN-GLY-GLY-SER-ASN
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
STF,SeruM ThyMic Factor,ThyMulin
GLP-ALA-LYS-SER-GLN-GLY-GLY-SER-ASN
STF
THYMIC FACTOR SERUM

Biological Activity

[Description]:

Serum thymic factor (Thymulin) is a zinc-dependent immunomodulatory peptide. Serum thymic factor induces hyperalgesia. Serum thymic factor protects rats from Cephaloridine (HY-B2072)-induced nephrotoxicity by inhibiting ERK activation. Serum thymic factor has anti-diabetic, analgesic and anti-inflammatory effects[1][2][3].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Dardenne M,et al. Role of thymulin or its analogue as a new analgesic molecule. Ann N Y Acad Sci. 2006 Nov;1088:153-63.

[2]. Kohda Y, et al. Protective effect of serum thymic factor, FTS, on cephaloridine-induced nephrotoxicity in rats. Biol Pharm Bull. 2005 Nov;28(11):2087-91.

[3]. Mizutani M, et al. In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice. Arch Virol. 1996;141(1):73-83.

Chemical & Physical Properties

[ Density]:
1.417 g/cm33

[ Boiling Point ]:
1658.9ºC at 760 mmHg

[ Molecular Formula ]:
C₃₃H₅₄N₁₂O₁₅

[ Molecular Weight ]:
858.85300

[ Flash Point ]:
957.1ºC

[ Exact Mass ]:
858.38300

[ PSA ]:
451.86000

[ Appearance of Characters ]:
white

[ Index of Refraction ]:
1.575

[ Storage condition ]:
−20°C

[ Water Solubility ]:
deionized water: soluble

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

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