Delapril

Names

[ Name ]:
Delapril

[Synonym ]:
Delaket (TN)
Alindapril
Glycine,N-(2,3-dihydro-1H-inden-2-yl)-N-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-,(S)
Glycine,N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-N-(2,3-dihydro-1H-inden-2-yl)
DELAPRIL
Delaprilum [Latin]
Delapril [INN]
Delaprilum

Biological Activity

[Description]:

Delapril (CV-3317) is an orally active angiotensin I converting enzyme (ACE) inhibitor. Delapril has antihypertensive activity[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

[In Vivo]

Delapril (5-20 mg/kg，饮用水喂养) 可减缓胆固醇喂养兔的动脉粥样硬化进展[2]。 Delapril (1-10 mg/kg，p.o.，每日一次，持续 5 周) 在高血压大鼠中表现出自发的抗高血压作用[3]。 Animal Model: Cholesterol-fed rabbits[2] Dosage: 5 mg/kg at D5, 10 mg/kg at D10, 20 mg/kg at D20 Administration: Fed in a fixed volume (10 ml) of drinking water Result: Decreased aortic area covered by lesions. Restored endothelium-dependent relaxation

[References]

[1]. Onoyama K, et al. Pharmacokinetics of a new angiotensin I converting enzyme inhibitor (delapril) in patients with deteriorated kidney function and in normal control subjects. Clin Pharmacol Ther. 1988 Mar;43(3):242-9.

[2]. Hernandez A,et al. Delapril slows the progression of atherosclerosis and maintains endothelial function in cholesterol-fed rabbits. Atherosclerosis. 1998 Mar;137(1):71-6.

[3]. Inada Y, et al. Antihypertensive action of a non-sulfhydryl angiotensin converting enzyme inhibitor (CV-3317) in various hypertensive models. Jpn J Pharmacol. 1986 Sep;42(1):1-8.