N-Acetyl-L-glutamic acid

Names

[ Name ]:
N-Acetyl-L-glutamic acid

[Synonym ]:
(2S)-2-(acetylamino)pentanedioic acid
EINECS 214-708-4
N-Acetyl-L-glutamicacid
AC-GLU-OH
N-acetyl-L-glutamate
(S)-2-acetamidopentanedioic acid
N-ACETYL-L-GLU
N-AC-L-GLU
MFCD00002802
N-Acetyl-L-Glutamic
N-Acetyl-L-glutamic Acid
N-acetyl-Glu
acetylglutamicacid
Acetyl-L-glutamic acid
2-(acetylamino)pentanedioic acid
L-Glutamic acid, N-acetyl-
NAcGlu
n-acetylglutamic
N-Acetylglutamate
n-acetylglutamicacid
l-glutamicaci

Biological Activity

[Description]:

N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[References]

[1]. M Hashimoto, et al. Animal cell culturing media containing N-acetyl-L-glutamic acid. Patent.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
495.9±35.0 °C at 760 mmHg

[ Melting Point ]:
194-196 °C(lit.)

[ Molecular Formula ]:
C₇H₁₁NO₅

[ Molecular Weight ]:
189.166

[ Flash Point ]:
253.7±25.9 °C

[ Exact Mass ]:
189.063721

[ PSA ]:
103.70000

[ LogP ]:
-2.24

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.502

[ Storage condition ]:
2~8°C

[ Water Solubility ]:
2.7 g/100 mL (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ9725000

CHEMICAL NAME :: L-Glutamic acid, N-acetyl-

CAS REGISTRY NUMBER :: 1188-37-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C7-H11-N-O5

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6838 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 711 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (3),36,1995

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
LZ9725000

[ HS Code ]:
29241900

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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