Azodicarbonamide
Names
[ CAS No. ]:
123-77-3
[ Name ]:
Azodicarbonamide
[Synonym ]:
Carbamoyliminourea
Diazene-1,2-dicarboxamide
(E)-carbamoyliminourea
MFCD00007958
EINECS 204-650-8
Chemical & Physical Properties
[ Density]:
1.9±0.1 g/cm3
[ Boiling Point ]:
241.3±23.0 °C at 760 mmHg
[ Melting Point ]:
220-225 °C (dec.)(lit.)
[ Molecular Formula ]:
C2H4N4O2
[ Molecular Weight ]:
116.079
[ Flash Point ]:
99.7±22.6 °C
[ Exact Mass ]:
116.033424
[ PSA ]:
110.90000
[ LogP ]:
-0.85
[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C
[ Index of Refraction ]:
1.680
[ Stability ]:
Highly flammable. Incompatible with strong oxidizing agents, strong acids, strong bases, heavy metal salts.
[ Water Solubility ]:
SOLUBLE IN HOT WATER
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LQ1040000
- CHEMICAL NAME :
- Formamide, 1,1'-azobis-
- CAS REGISTRY NUMBER :
- 123-77-3
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C2-H4-N4-O2
- MOLECULAR WEIGHT :
- 116.10
- WISWESSER LINE NOTATION :
- ZVNUNVZ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >6400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 440 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory stimulation Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/10D-C
- TOXIC EFFECTS :
- Endocrine - evidence of thyroid hypofunction Endocrine - changes in thyroid weight
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 233 gm/kg/4W-C
- TOXIC EFFECTS :
- Endocrine - evidence of thyroid hypofunction
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 207 mg/m3/6H/2W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 204 mg/m3/6H/13W-I
- TOXIC EFFECTS :
- Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 252 mg/kg/1W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - hematuria Related to Chronic Data - death
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 217 mg/m3/6H/2W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 204 mg/m3/6H/13W-I
- TOXIC EFFECTS :
- Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 8(Suppl 7),1,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81713 No. of Facilities: 1753 (estimated) No. of Industries: 32 No. of Occupations: 60 No. of Employees: 43147 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81713 No. of Facilities: 1210 (estimated) No. of Industries: 18 No. of Occupations: 29 No. of Employees: 42296 (estimated) No. of Female Employees: 17091 (estimated)
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H334
[ Supplemental HS ]:
Risk of explosion if heated under confinement.
[ Precautionary Statements ]:
P261-P284-P304 + P340-P342 + P311
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R42;R44
[ Safety Phrases ]:
S22-S24-S37
[ RIDADR ]:
UN 3242 4.1/PG 2
[ WGK Germany ]:
1
[ RTECS ]:
LQ1040000
[ Packaging Group ]:
II
[ Hazard Class ]:
4.1
[ HS Code ]:
2924199090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2927000090
[ Summary ]:
2927000090 other diazo-, azo- or azoxy-compounds。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
Articles
J. Med. Chem. 41(9) , 1371-81, (1998)
Agents that target the two highly conserved Zn fingers of the human immunodeficiency virus (HIV) nucleocapsid p7 (NCp7) protein are under development as antivirals. These agents covalently modify Zn-c...
Assessment of the determination of azodicarbonamide and its decomposition product semicarbazide: investigation of variation in flour and flour products.J. Agric. Food Chem. 59(17) , 9313-8, (2011)
Azodicarbonamide, as a bleaching agent and improving agent, is a permitted food additive in certain countries and can be determined by high-performance liquid chromatography. However, it partially deg...
Comparative studies by IR, Raman, and surface-enhanced Raman spectroscopy of azodicarbonamide, biurea and semicarbazide hydrochloride.Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 80-4, (2013)
Azodicarbonamide is widely applied in the food industry as a new flour gluten fortifier in China, Canada, the United States, and some other countries, whose metabolites of biurea and semicarbazide hyd...