4-Nitrophthalimide

Names

[ CAS No. ]:
89-40-7

[ Name ]:
4-Nitrophthalimide

[Synonym ]:
1H-Isoindole-1,3(2H)-dione, 5-nitro-
4-Nitrophthalimide
4-nitro-phthalimid
5-NITROPHTHALIMIDE
4-Nitrophtalimide
5-Nitro-1H-isoindole-1,3(2H)-dione
3-nitrophthalimide
4-Nirtophthalimide
5-Nitroisoindoline-1,3-dione
5-Nitro-isoindolin-1,3-dion
4-nitro-phthalimide
5-nitrosoindoline-1,3-dione
EINECS 201-905-5
5-nitro-isoindole-1,3-dione
P-NITRO-PHTHALIMIDE
PHTHALIMIDE,4-NITRO
MFCD00005884

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
206 °C

[ Molecular Formula ]:
C₈H₄N₂O₄

[ Molecular Weight ]:
192.128

[ Exact Mass ]:
192.017105

[ PSA ]:
91.99000

[ LogP ]:
0.88

[ Index of Refraction ]:
1.658

[ Stability ]:
Stable. Combustible. Incompatible with moisture, water, strong oxidising agents, strong bases.

[ Water Solubility ]:
<0.01 g/100 mL at 18 ºC

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TI5625000

CHEMICAL NAME :: Phthalimide, 4-nitro-

CAS REGISTRY NUMBER :: 89-40-7

BEILSTEIN REFERENCE NO. :: 0180224

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C8-H4-N2-O4

MOLECULAR WEIGHT :: 192.14

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 333 ug/plate

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 11(Suppl 12),1,1988

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
TI5625000

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

An approach for evaluating and increasing the informational content of mutagenicity and clastogenicity data bases.

Mutagenesis 8(3) , 257-64, (1993)

A method is described for using the fragments identified by the CASE structure-activity relational expert system to identify the type of chemicals that require further testing in mutagenicity and clas...

Colorimetric detection of achiral anions and chiral carboxylates by a chiral thiourea-phthalimide dyad.

Photochem. Photobiol. Sci. 9(10) , 1385-90, (2010)

The chiral chemosensor 1, based on a thiourea-activated phthalimide, is available by four reaction steps from 4-nitrophthalimide. 1 detects fluoride, chloride, acetate, and dihydrogen phosphate anions...

Design, synthesis and protection against pentylenetetrazole-induced seizure of N-aryl derivatives of the phthalimide pharmacophore.

Med. Chem. 8(5) , 953-63, (2012)

A series of compounds including N-aryl substituents of phthalimide and 4-nitrophthalimide were synthesized and evaluated for their anticonvulsant properties. The in vivo screening data suggest that al...