Published date: 2024-01-21 16:36:45
CAS number: 1452458-86-4
Name: OP-0595
Price:
￥15000.0/1g
￥Inquiry/10g
￥5000.0/100mg
￥Inquiry/500g
Purity: 98.0%
Stocking period: 2 Day
Stock: In Stock
Product Webpage: http://www.wetogethermed.com/product/2337.html
Detail Product Information:
Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs.
Nacubactam is a Phase 3-ready beta-lactamase inhibitor which works through multiple mechanisms of action, inhibiting a number of beta-lactamase enzymes as well as certain bacterial cell wall enzymes, lending the candidate a broad spectrum of activity when used in combination with beta-lactam antibiotics. In non-clinical studies, nacubactam-meropenem was shown to have potent antimicrobial activity against complicated urinary tract and severe respiratory tract infections, including those caused by meropenem-resistant strains, and against infections caused by CRE. In previously reported Phase 1 clinical studies, it was demonstrated that intravenous nacubactam was well tolerated among healthy volunteers when administered alone or in combination with meropenem. In these studies, nacubactam had no effect on ECG or vital signs parameters, and no trends in laboratory tests were observed. Pharmacokinetic studies in renal impaired patients and in cUTI patients have also been completed.
Name: Hebei We Together Medical Technology Co., Ltd.
Chemsrc Level: Unverified
Product #: 14
Tel: 13180081292
Address: China,Hebei Province,Shijiazhuang city,High-tech District,Taishan Street No. 219-19, Second floor
Area: China(Mainland)
Contact: Richard Wang
Contact Phone #: 13180081292
Email: wetogethermeditech@163.com
Website: http://www.wetogethermed.com
Annual Trade Volume: 100w
Foreign Trade % of Salers:
Major partners:
Detail
introduction:
Hebei We-Together Meditech Co., Ltd. focus on Antibiotic enhancement agent (Antibiotic Enhancer) especially for β-lactamase inhibitor pipeline drugs as the business line, provides Avibactam, Relebactam, Zidebactam, Vaborbactam, WCK-5153, etc Series of β-lactamase inhibitors intermediates, impurities, R & D production, technical services and technology transfer ,etc.
Name: Shanghai Nianxing Industrial Co., Ltd
Area: China
Price:
￥15000.0/1g
￥Inquiry/10g
￥5000.0/100mg
￥Inquiry/500g
Contact: Yang
Product Detail: OP-0595
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