<Suppliers Price>

Kushenol E

Names

[ CAS No. ]:
99119-72-9

[ Name ]:
Kushenol E

[Synonym ]:
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-, (2S)-
(2S)-2-(2,4-Dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)-2,3-dihydro-4H-chromen-4-one
4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-6,8-bis(3-methyl-2-butenyl)-, (S)-

Biological Activity

[Description]:

Kushenol E is a class of flavonoids isolated from Sophora flavescens and is a non-competitive indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with an IC50 of 7.7 µM and a Ki of 9.5 µM, has anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Kwon M, et al. Inhibitory effects of flavonoids isolated from Sophora flavescens on indoleamine 2,3-dioxygenase 1 activity. J Enzyme Inhib Med Chem. 2019 Dec;34(1):1481-1488.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
674.8±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H28O6

[ Molecular Weight ]:
424.486

[ Flash Point ]:
230.7±25.0 °C

[ Exact Mass ]:
424.188599

[ LogP ]:
6.66

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.632

Related Compounds