TBTU
Names
[ CAS No. ]:
125700-67-6
[ Name ]:
TBTU
[Synonym ]:
TBTU;; O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
(1H-Benzotriazol-1-yloxy)(dimethylamino)-N,N-dimethylmethaniminium tetrafluoroborate
[benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium,tetrafluoroborate
N,N,N',N'-Tetramethyl-O-(benzotriazol-1-yl)uronium Tetrafluoroborate
Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, tetrafluoroborate(1-)
N,N,N′,N′-Tetramethyl-O-(benzotriazol-1-yl)uronium tetrafluoroborate
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate
MFCD00077413
Methanaminium, N-[(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methyl-, tetrafluoroborate
T56 BNNNJ BOYN1&1&UK1&1 &&BF4- salt
N-[(1H-Benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate
2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetram
N-[(1H-1,2,3-Benzotriazol-1-yloxy)(dimethylamino)methylene]-N-methylmethanaminium tetrafluoroborate
N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylidene]-N-methylmethanaminium tetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate (TBTU)
EINECS 423-040-4
O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate
O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
TBTU
Chemical & Physical Properties
[ Melting Point ]:
205 °C (dec.)(lit.)
[ Molecular Formula ]:
C11H16BF4N5O
[ Molecular Weight ]:
321.082
[ Flash Point ]:
STABILITY
[ Exact Mass ]:
321.138397
[ PSA ]:
46.19000
[ LogP ]:
1.34960
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
acetonitrile: 0.1 g/mL, clear
MSDS
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H228-H315-H319-H335
[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi:Irritant
[ Risk Phrases ]:
R36/37/38;R5
[ Safety Phrases ]:
S26-S36-S37/39
[ RIDADR ]:
UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
[ WGK Germany ]:
3
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
Antimicrob. Agents Chemother. 52 , 3229-36, (2008)
The lack of novel antibiotics against gram-negative bacteria has reinstated polymyxins as the drugs of last resort to treat serious infections caused by extremely multiresistant gram-negative organism...
S. Zimmer et al., C.H. Schneider and A.N. Eberle, eds.Proc. 22nd Eur. Pept. Symp.: Peptides 1992 Leiden 1993, p. 393
O-(BENZOTRIAZOL-1-YL)-N, N, N', N'-TETRAMETHYLURONIUM TETRAFLUOROBORATE (TBTU): A NEW REAGENT FOR THE CLEAVAGE OF TETRAHYDROPYRANYL, SILYL AND 4, 4'-D IMETHOXYTRITYL ETHERS. Ramasamy KS and Averett D.
Synlett 6 , 709-712, (1999)