Y-27632 dihydrochloride Price from Supplier Brand Chemleader Biomedical Co., Ltd. on Chemsrc.com

Published date: 2024-09-11 15:56:57

CAS number: 129830-38-2

Price:
￥Inquiry/1g ￥Inquiry/5g ￥Inquiry/10g ￥Inquiry/50g

Purity: 98.0%

Stocking period: Inquiry

Stock: In Stock

Detail Product Information:
Product Name: Y-27632 dihydrochloride; Y-27632 2HCl
CAS No.: 129830-38-2; 146986-50-7
Chemical Name: trans-4-[(1R)-1-Aminoethyl]-N-4-pyridinylcyclohexanecarboxamide dihydrochloride; 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride; (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride; (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
Molecular Formula: C14H21N3O.2HCl
Molecular Weight: 320.26
Appearance:White solid
Purity(HPLC): >99%
Biological Activity: Selective inhibitor of the Rho-associated protein kinase p160ROCK. Ki values are 0.14, 26, 25 and > 250 μM for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC50 = 600 nM). Smooth muscle relaxant and orally active in vivo. Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCKI (Ki = 220 nM) and ROCKII (Ki = 300 nM) by competing with ATP for binding to the catalytic site. Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways. Y-27632 selectively inhibits p160ROCK.
Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP.

Name: Chemleader Biomedical Co., Ltd.

Chemsrc Level: Unverified

Product #: 40

Tel: +8621-58180488

Address: 5/F,Building 25,No.3399 Kangxin Highway,Shanghai International Medical Zone(SIMZ),Pudong New District,Shanghai 201318, P.R. China

Area: China(Mainland)

Contact: Chemleader

Contact Phone #: +8621-58180488

Email: sales@chemleader.cn

Website: http://www.chemleader.com.cn

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Detail introduction:
Chemleader Biomedical Co., Ltd. was founded in 2010, is a professional research chemical supplier specializing in R&D, manufacturing and sales. The headquarters is located in Shanghai International Medical Zone(SIMZ), Pudong New District, Shanghai, China, with over 30000 square feet sales office/ research laboratory and 20000 square feet pilot plant. Our branches in Jiangsu, Shandong, and Hong Kong.
We are committed to provide the highest quality products and the best service to pharmaceutical company and scientific research institutions in China and international markets. Our team has had extensive expertise and an excellent background in synthetic chemistry, project management, CRO, QC/QA, pilot plant etc.
As an innovation-driven and customer-focused company, we also specialize in custom synthesis of organic compounds, various drug intermediates as well as a variety of specialty and fine chemicals ranging from milligram to tons scale.

With our whole Professional team's efforts for many years we gain the admiration and trust from the domestic and overseas clients, and favorable position and Reputation in China Pharmaceutical and Fine Chemicals field. We are devoted to decreasing the production cost, optimizing the artwork, creating and keeping the accomplishment of best environmental, health, and safety performance in the industry.

Core Values:
"Customer First" "People-Oriented" "Sustainable Innovation" "Teamwork"

Mission:
To be a leader in the global pharmaceutical and chemical research and development field by providing our clients with top quality products and service.

Vision:
To be recognized by its clients as the best pharmaceutical partner for its superior quality, efficient and cost-effective services;
To be recognized by its competitors as a responsible and competitive team for its spirits of innovation, matter-of-fact attitude, high efficiency of operations and the strategy of sustainable growth .
To be recognized by its employees as a respectable employer for offering professional training, and career opportunities.